Highlights
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Today’s Research Article: Early OA? One injection of PRP or HA helps—PRP moves the needle faster.
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Questions from the Field: If you measure it, you can price it—structure PRP fees around proven value.
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Let’s Get Down to Business: Reclaim your practice—innovate clinically, communicate publicly, mentor boldly.
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Come Join Us - Your October sprint: TrueMD Live → ICRS → Apex Lab → AOAO.
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Today’s Research Article
Comparing the Efficacy of Intra-Articular Single Platelet-Rich Plasma(PRP) versus Novel Crosslinked Hyaluronic Acid for Early-Stage Knee Osteoarthritis: A Prospective, Double-Blind, Randomized Controlled Trial
Ying-Chun Wang, Chia-Ling Lee, Yu-Jen Chen, Yin-Chun Tien, Sung-Yen Lin, Chung-Hwan Chen, Paul Pei-Hsi Chou and Hsuan-Ti Huang
Summary:
This double-blind RCT (n=110; K-L I–II) compared a single leukocyte-poor PRP injection (~4 mL) to a single crosslinked HA (HyajointPlus, 3 mL) for early knee OA. PRP produced significant improvements in WOMAC pain, function, and total at 1, 3, and 6 months (stiffness significant by 3 and 6 months). HA improved pain at all time points, while stiffness, function, and total reached significance only at 6 months.
Between-group comparisons showed no statistically significant differences at 1, 3, or 6 months; by 6 months both groups achieved ~23% mean improvement in WOMAC total from baseline. Safety was good overall; no serious adverse events were reported (a few transient post-injection swellings in the HA arm). Bottom line: both single-injection PRP and crosslinked HA improved symptoms through 6 months, with PRP showing earlier, broader improvements across WOMAC domains.
Doctor-to-Patient Talking Points on Why to Choose PRP (Based on the Study):
