Highlights
- Today’s Research Article: PRP Outperforms Steroids in Knee OA Relief and the Results Last.
- Questions from the Field: It’s Not the Centrifuge, It’s What You Do With It.
- Let’s Get Down to Business: Stop blending in. Learn how patient stories and consistency can turn followers into patients.
- Come Join Us: Join us in Vegas this July and August for two powerful regenerative medicine experiences you won’t want to miss.
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Today’s Research Article
Clinical and Biochemical Correlation of Intraarticular Platelet-Rich Plasma and Corticosteroid Using Serum Matrix Metalloproteinase 3 (MMP-3) Levels in Osteoarthritis of Knee
Vaneet Arora, Manmohan Sharma, Sandeep Bishnoi, Vakul Mahipal, Angad S. Sandhu, Rajat Khanna, Tarun Aggarwal, Krishnadev S. Yadav, Gautam Jain, Shubham M. Sharma
Summary:
This study compared the clinical and biochemical outcomes of intra-articular Platelet-Rich Plasma (PRP) versus corticosteroid (CS) injections in patients with knee osteoarthritis (OA). A total of 87 patients with Kellgren-Lawrence grade II and III knee OA were randomly assigned to receive a single injection of either PRP or methylprednisolone. Outcomes were assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the Visual Analogue Scale (VAS), and serum levels of Matrix Metalloproteinase-3 (MMP-3). Patients were followed up over nine months.
The findings revealed that PRP provided significantly greater and longer-lasting improvements in pain, stiffness, and joint function compared to CS, as evidenced by lower WOMAC and VAS scores at the 6- and 9-month marks. However, neither treatment led to a significant change in serum MMP-3 levels, suggesting that while both offer symptomatic relief, neither appears to alter cartilage degeneration biochemically. PRP was also found to be safe and minimally invasive, reinforcing its clinical utility in OA knee management.
Doctor-to-Patient Talking Points on Why to Choose PRP (Based on the Study):
